Orally bioavailable amino acid inspired small molecules (AISM)

•Presence of distinct interface of PPIs involving the loops/strand sequences can be exploited in identifying peptides that mimic the native interaction interface

•Native interaction pharmacophore identified by the reductionist approach comprising of < 10 amino acids

•Conversion of linear peptides into peptidomimetics and further SAR optimization resulting  in orally available amino acid inspired small molecule inhibitors

Expertise in converting peptide into amino acid inspired small molecules

Reference:

Sasikumar et al., Commun Biol 4, 699 (2021). https://doi.org/10.1038/s42003-021-02191-1

Sasikumar and Ramachandra, Front. Immunol. (2022) 13:752065. doi.org/10.3389/fimmu.2022.752065